First of all, when you read about a "50W LED", it is certainly saying that it outputs the equivalent light of a 50W incandescent light (although that is often a exaggeration). That "50W" LED actually draws less than 10 watts. This means that it draws much less current and emits much less heat, both of which are the factors that typically limit the allowable light in a fixture.
You'd be able to replace a 50/100/150W 3-way with a lower wattage, even if staying with incandescent.
Second, unless the LED light is marked "dimmable", don't try to use it on a dimmer. You may damage the dimmer, light, or both. Even if the light is dimmable, some dimmers will not work well with a low load: a dimmer that works on a 100W light bulb may not work on an equivalent-light-output 13W LED. They make LED/CFL specific dimmers that may work better.
As for the 130V R40, that is probably a "long life" bulb. Running an incandescent at lower than rated voltage extends its life. Therefore, they make 130V bulbs to run longer on 120V. Just use LEDs rated for 120V.
As for your existing florescent lighting, I assume you're talking about the straight tube type. For a fixture that old, it's probably less efficient that newer florescent fixtures or LEDs but still much more efficient than incandescent. This is harder to replace with LEDs, just due to the area covered. There are LED tubes made to replace florescent tubes but they are still expensive and generally require re-wiring the fixture. These are most often used in commercial applications.
Best Answer
The manufacturer wisely states that their bulb should not be used in a fully enclosed fixture. (this is true of incandescents as well.) (it is always a bad idea to trap heat) However if you are replacing your old incandescent bulb with an LED you will need about 1/6 the wattage to produce the same lumens. (the actual brightness of light emitted). A 25-watt bulb LED will replace a 150-watt incandescent. Regarding the seeming contradiction you see in the lamp instructions; it is possible to have a globe type fixture that is vented. They just don't want their bulbs in a non-vented globe fixture. It shortens the life of the bulb.