Permanently closing off a crawl space under a house

Here is the solution I implemented to fix this issue and ultimately brought the humidity level to a stable 58%:

-First and foremost the first thing I did was get a Meade Instruments TM005X-M so I could measure the humidity levels in my crawl space and get a baseline. My starting humidity levels were 75%-88%, most likely hitting 100% over the summer.

-I Had a contractor come out and replace gutters, adding two downspouts to the front of the house. In addition I will be digging trenches to send the water at least 10 feet away from the house. This was necessary because there were no downspouts on the front of the house and the water would pour over the sides of the gutters.

-I then laid out 6mil black plastic on about 75% of the dirt in the crawl space. This alone lowered the humidity from 88% to around 75%. I did not remove all of the rocks, and even after crawling on it with kneepads it did not break or tear the plastic. We did remove some of the obnoxiously large Ozark rocks. The 6mil plastic (recycled even) ($75.00) is very strong. I did a 12"-24" overlap and did not seal the seams. We did not go up the wall. We staked it down with garden stakes ($8). It is by no means perfectly sealed, but is covered.

-I sealed up all of the crawl space vents (6) with 1.5" foam, and used expanding foam to make sure the seal was good. ($30.00)

-I installed the humidifier and set it to run in continuous mode. The humidifier model I ended up getting was the FFAD7033R1 which can run in continuous mode by hooking a hose up to it. This hose drains to the sump pump. The sump pump did not have a lid, so I purchased a standard 5gal bucket lid and used waterproof duct tape to seal the lid onto the sump pump, then drilled a hole in it for the hose to come through. This put us around 65% humidity. Later I will set this to a specific humidity to hold at, and it will only run when needed. ($250.00)

-Finally, we covered the final 25% of the crawl space with the same 6mil plastic. During this time we discovered standing water, a couple 1/4" deep small puddles near the front of the house (north, the bad spot). At this time I inspected the area thoroughly and found that the sewer line going through the foundation and out had no sealer around it. This left a 1/2" gap around the entire pipe, going directly to the dirt. Under the pipe there was mud-like residue, so I was now certain this was the root issue. We used expanding foam sealer around the pipe, and laid the 6mil plastic over the puddles. This final step brought us to 58%, and I am confident it will continue to drop.

All in all, I was quoted $10,000.00 to fix this problem with a CleanSpace® system, and ended up spending around $450.00 max plus my time, about 20 hours to fix it myself. Note I don't count the gutters as included in the price since they were old and failing already. Also, the solution from the contractor did not include solving outside water problems, which in my opinion is where you should start.

Additional note about sealed vs unsealed crawl spaces. There is tons of conflicting information on this subject so I decided to test for myself. On a day when the humidity was around 55% outside, and the humidity was around 70% in the crawl space, I setup box fans to suck the 55% humidity air from the outside into the crawl space for around 12 hours straight. Doing this lowered the humidity only by 1-2%, so I knew sealing my vents was the answer.

It may seem counter-intuitive, but when dealing with crawl space issues START OUTSIDE.

It appears to me that all of the vertical walls are load-bearing. If I assume the roof to the crawl space is a reinforced concrete slab, it's live and dead loads would likely bear parallel and perpendicular to the side walls.

You can move the opening. But because the existing construction of the crawl space roof is unknown and, like-wise, exactly how it bears on the walls, I suggest you create the new opening in a mirror image to the existing opening. In other words, from your picture, use the measurement from the left side of the opening to the wall to the left as your new right side opening measurement from the corner, but do add to that length the width of the the wall.

Lastly, yes it would be more difficult to do the work after adding the new AC compressor because it is best to fill the existing opening with load-bearing material, such as concrete block, and finish the exterior to best match the walls. Once that's finished you won't have a possible interference with the AC compressor.