Yes, it is possible to use "ever since" with the present perfect. "Ever since" links two events, a cause event and something that is true from that point in time onward. This is actually ideal for the present perfect tense because one of the uses of the present perfect tense is to indicate that something which began in the past is still relevant in the present. An example of this use is your sentence:
"I always thought it was wrong, but ever since I read it, I've been more confused."
Using the present perfect with "ever since" shows that the speaker has been and is still confused by something which they read in the past.
With the past simple tense, as in your last sentence, it would be more appropriate to use "once" instead of "ever since". This is because "once" links a cause event with something that changed, but does not necessarily link to the present.
Once I did that, it stopped bothering me.
This sentence shows that the speaker was not bothered by "it" as soon as they did "that". It however gives not indication of whether this continues to be true in the present.
I saw your edit, if I understand right you meant to ask if it is possible to use "ever since" and present perfect without past simple, which would look something like:
"ever since" + present perfect + present
Ever since I have been pregnant I feel sick each morning.
The answer is no, this is not natural English. This structure may be encountered in informal English, but it is more natural to have the structure:
"ever since" + past simple + present perfect
Ever since I got pregnant I have felt sick each morning.
- We use the present perfect to talk about an experience at any time in the past. The exact time of the experience isn't important.
I've seen the latest Megan Fox Film. Have you ever been to Spain?
- We use the past simple to talk about a specific occassion in the past.
I saw the latest Jim Carrey film last night. Did you go to Spain last summer?
So, in your example, the tense is,
I have never felt appreciated in my whole life.
Best Answer
There is a difference between
and
The first one asks if you have never ever paid bills. The second one asks if you, at one time or another, did not pay a bill.
Both sentences are correct; I'm just not sure which one they want to hear ;)
By the way, you can use sentences with "Did" if you want.
and
But you can't use "have" and "did" in the same sentence.