Individual is indeed a noun and an adjective. When used as a noun, it refers to a person, or someone. For example:
That individual over there is a nasty piece of work.
To give a couple of examples of the use of the adjective, using heartbeat in its singular and plural:
Singular
You can feel each individual heartbeat when you take someone's pulse.
Or
When I put my hand to your chest I can feel every individual heartbeat
Note: when singular, individual would be preceded by each, every, one, an, or the.
Plural
If you add up all of the individual heartbeats, and divide them by the
time you felt them in, that will give you the person's heart rate.
Summary
So, in short, use individual heartbeat if you are talking about one particular heartbeat, or individual heartbeats when referring to the separate heartbeats as an ensemble.
In the example that you provide,
Morphological and statistical features of individual heartbeats are
used to...
you are referring to the features of a collection (plural) of heartbeats (even though, you are considering each and every individual heartbeat), and so you are correct in using individual heartbeats
In this context, we can assume that each machine has its state, so it's correct to use states as we're talking about different entities (machines) with different and independent aspects (states), even if they were the same state in all machines.
On the other hand, if we were talking about the general state of the set of machines, then the plural would be wrong, considering we're yet talking about different entities (machines) but they have aspects (state) which are dependent on each other.
Best Answer
Knowledge is uncountable, and so does not normally take either an indefinite article, or a plural ending. Like other uncountables, it can sometimes be used as countable, when it refers to a specific instance or a particular type (I mention this for completeness: it's not relevant in your example)
Means (in this sense) is singular, despite its -s ending. It can also be plural, so the article a is used when it is singular, not when it is plural.
Since knowedge is (uncountable and) singular, singular means is most appropriate here.
So the most idiomatic of your options is: