Learn English – What’s the difference between “Don’t fight me.” and “Don’t fight with me.”

Just to put Davo's answer in as an answer, with a little more explanation...

In terms of the most essential meaning in this context, "in" and "with" have the same meaning. They both introduce adverbials indicating what it took to do what was done. "He broke the thick sheet of glass" stands as a sentence on its own, but is modified by the adverbial of manner "in one hit" or "with one hit". Both "in" and "with" can have other meanings, but here they introduce the same sort of adverbial. Adverbials of manner tell you how or in what way something is done.

However, as Davo notes, they carry different shades of meaning. "With" is more neutral than "in", as with would be more likely to be used if there is no surprise, and in makes it seem more remarkable. You can also indicate that you consider it remarkable by adding the word "just" - "in just one hit".

Generally and usually are synonyms when they refer to the frequency or likelihood of something happening under normal circumstances, or to what is common or unexceptional practice.

We generally go to the beach during vacation.

We usually go to the beach during vacation.

But generally can also refer to a class, especialy in terms of a common attribute, and we cannot use usually there.

When she said people tend to exaggerate, she meant people generally. A tendency to exaggerate is a trait of people all over the world. It is a human trait. But maybe exaggeration varies from culture to culture?