Learn English – I need a word for things not going your way

In some cases, cataclysm (“A sudden, violent event”) will work. Also consider:
• crisis (“A crucial or decisive point or situation; a turning point”)
• turning point, “A decisive point at which a significant change or historical event occurs, or at which a decision must be made”
• crossroads, “A decision point; a turning point or opportunity to change direction, course, or goal”
• watershed, “A critical point marking a change in course or development”

Perhaps you are looking for "novelty seeker"? In the psychological sense, the meaning might be a bit strong, but, generally, someone who enjoys having new/different/a range of experiences could be said to seek novelty. I certainly use the term of myself. "Thrill seeker", of course, would work if the types of experiences are adrenaline inducing.

And I just found this:

Definition of NEOPHILIA: love of or enthusiasm for what is new or novel

So "neophile" would also work.