Best regards seems to be quite a popular valediction used in business emails, along with variants kind regards, or just regards.
The spoken expression "give him my regards" would appear to be a suitable starting point for the written valediction Regards, but when did this become best regards? Has it ever existed in written letters?
Best Answer
In a letter from Queen Elizabeth I, dated 1601, there's the valediction "Your Sovereigne that best regards you." I doubt that this is the first appearance of the phrase "best regards" (and actually, here it's an adverb + verb, whereas as used nowadays it's more of an adjective + noun); but at least it probably means that "best regards," as an ending for a letter, probably started out something like that and was later clipped.