As a matter of style, many U.S. publishers follow the general rules given by the Chicago Manual of Style, fifteenth edition (2003) at 7.51, 7.53, and 7.54 under the heading "FOREIGN WORDS":
7.51 Italics. Italics are used for isolated words and phrases in a foreign language if they are likely to be unfamiliar to readers. [Examples omitted.]
...
7.53 Proper nouns. Foreign proper nouns are not italicized in an English context. [Examples omitted.]
7.54 Familiar foreign words. Foreign words and phrases familiar to most readers and listed in Webster are not italicized if used in an English context; they should be spelled as in Webster. ...
Guideline 7.54 is the relevant one for your question about sans—and any other arguably foreign word you might be thinking of using. If the word is in the English dictionary that you normally use (and it doesn't have to be a Merriam-Webster product, Chicago's wording notwithstanding), you may treat it as an adopted English word and thus as not requiring italics to indicate its foreignness. This certainly is the case with sans, which has been in use in English since the fourteenth century (according to MW) and appears in such memorable quotations as Jaques's speech about the seven ages of man, in Shakespeare's As You Like It:
Last scene of all,/That ends this strange eventful history,/Is second childishness and mere oblivion,/Sans teeth, sans eyes, sans taste, sans everything.
So if you're inclined to follow Chicago's lead on this question, have a dictionary handy when you prepare to use what may or may not be viewed as a non-English word.
Best Answer
This is ultimately a style question, and style questions are the province of individual authors or of the publishing houses responsible for producing their work.
At the magazines and book publishers where I've worked, we generally followed the "primary system" recommended in Chicago Manual of Style, fifteenth edition (2003):
Rendered in accordance with this guideline, your example would appear this way:
As you can see, kombi is italicized, but the single open and close quotation marks, the question mark, and the double close quotation mark are not.
Chicago also presents (at 6.5) an alternative system in which a period, comma, colon, or semicolon immediately following an italicized word receives italic treatment along with the word preceding it. But that system wouldn't apply to the quotation marks or to the question mark in your example in any case.
The one exception to Chicago's guideline 6.3 that some of the magazines where I've worked introduced involved apostrophes following italicized words: Because the apostrophe often crashed into the final italicized letter of the preceding word, we set the apostrophe as italic, too. Thus:
It is worth reiterating, though, that style decisions regarding punctuation are not matters of universal rule, but of individual or house preference. As in other such matters, the most important practical consideration is to maintain consistency across the book, article, or publication series.