the-binding-of-isaac-rebirth
In Binding of Isaac: Rebirth there are various challenges which spawn you with equipped items.
What I'm wondering is if the levels are also fixed or vary each time you try the challenges. If I come across some really cool level run, will it be the same next time I try this challenge, or are they randomly generated like the 'normal' game?
I've asked the same question on the SteamCommunity Forum, and this is the outcome:
Nope, they don't sadly.
I know because I've tried it, was getting nothing but Breakfast which meant I had exhausted the entire pool. But none of the items that I needed to find were in the collection page.
EDIT:
There are different opinions, so it's a bit confusing, another guy posted this answer:
I haven't unlocked these yet and somehow they're there.
Meaning that he hasn't unlocked The Lost items (The Soul, The Body and The Mind) but they are shown in his collection page. So it appears to be true.
Judging by the question date is quite likely you already resolved this. But I'll answer for future generations.
If you start steam on the PC it will overwrite the local save. So you have to:
Steam will update the cloud save file with your backup then.
Best Answer
No, they are randomly generated like any normal run. Restarting, you can see that the map and the first room pattern always change.
Challenges typically start the player off with one or more specific items which make normal play more difficult. That's the only fixed thing on each try.
Note that new content (Achievements or Secrets), other than the Reward, cannot be unlocked. Likewise, you will not find a Donation Machine anywhere.
And if you find and collect new items they don't show in the Collection Page.
Only the Daily Challenge is pre-seeded. [Afterbirth DLC only]