I found (annoyingly) that the "Up High, Down Low" challenge for giving Claptrap a high-five is one time only.
Before I miss any one-chance challenges later in the game, what other challenges/achievements are missable inside a single playthrough?
Borderlands – What achievements/challenges are missable
achievementsborderlands-2
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Best Answer
According to Xbox360Achievements.org, there are no missable achievements. Even Up High, Down Low can be completed later on as there are other opportunities to high five Claptrap (including one right before the end of the game).