I noticed after getting a seed from my friend, ands beating the boss rush (for the first time with cain) I didn't unlock anything. Also I had a seeded run to get Guppy, but that also didn't unlock anything. Do seeded runs count towards anything? Do donation machines show up on seeded runs, and if so, do donations made on seeded runs count?
The Binding of Isaac Rebirth – Can Items Be Unlocked in Seeded Runs?
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Related Solutions
I've asked the same question on the SteamCommunity Forum, and this is the outcome:
Nope, they don't sadly.
I know because I've tried it, was getting nothing but Breakfast which meant I had exhausted the entire pool. But none of the items that I needed to find were in the collection page.
EDIT:
There are different opinions, so it's a bit confusing, another guy posted this answer:
I haven't unlocked these yet and somehow they're there.
Meaning that he hasn't unlocked The Lost items (The Soul, The Body and The Mind) but they are shown in his collection page. So it appears to be true.
The Adversary picks a direction to shoot, then charges up, then shoots. And the homing only goes so far. When you expect him to fire that brimstone, just do a quarter turn around him. Or you can constantly move, circle around him without stopping, and the shots won't get you.
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Best Answer
If you enter a seed, you will not be able to earn achievements or unlock items during that run in most cases but some seeds such as "qwop qwop" will still enable achievements while being a consistent seed. There is also no donation machine in the shop (but shop upgrades from previous runs still make more items available).
This is shown by the no achievement icon: