There are several conversation achievements (listen to every Blacksmith, Jeweler, Cain, Leah, Tyrael, Adria, town merchants, followers, etc.). Is it possible to miss any of these by not talking to them at a specific time? If so, which, and when?
Diablo – Are any conversation achievements missable
achievementsdiablo-3
Related Solutions
From what I've seen and gained, there is maybe only one that is missable. However, you will have a second chance to get it if you go through a New Game Plus to get that achievement.
Catch
This one is not related to the main story, and is related to another achievement Mystery Stalker. You only meet a certain person 5 times during the game, and after that they are gone. You have to throw a remote controlled batarang at them.
In addition to the ones you mentioned, the following achievements may give you trouble..
I Love Shopping - Buy first Upgrade - if all of the Skylanders already have one+ upgrade
Climb to the Top - Level Up to 10 - If all Skylanders are already at 10
True Portal Master - all other Achievements - obviously, if you can't get any of the others
Note that you can reset a Skylander to level 1, or transfer it to someone else. Look under the Manage option in the Menu.
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Best Answer
While you might be able to miss a required conversation when playing strictly linearly, you don't have to play strictly linearly.
Diablo 3 is broken up into quests, and since you can start from any quest you've unlocked, you can jump back to whatever conversation you have missed if you go too far, too fast.
Once you've unlocked all the acts in a given difficulty, you can jump anywhere you want, at any time, so it becomes less an issue of "missing" a conversation than it is "figuring out which conversations I've yet to have". (And then jumping directly to the relevant quest)