Diablo – Can a Random Property on Weapons Spawn more than one Bonus

Class specific weapons can provide some class only enchantments that you cannot get on standard weapons. Whether or not this is worth a trade off for damage, that is entirely up to you to decide.

For instance, you can find a demon hunter only 1 handed crossbow that provides hatred regeneration or a wand for mages that provides improved arcane pool.

Like James mentioned in his answer, the demon hunter is the only class that has a unique situation where you MUST have a ranged weapon equipped or you can't use his ranged attack skills. And his one handed crossbow is the only ranged weapon you can dual wield.

Way of the Hundred Fists consists of 3 attacks, which appear to be 1 hit, 5 fast hits, than 1 hit again.

The 5 fast hits counts as one hit for any on-hit effect.

For example, if you have 0 spirit and use the full Way of the Hundred Fists combo, you will have 18 spirit since it gives you 6 spirit per attack.

I also tested this with on-hit effects by removing all equipment except a weapon with an amethyst in it (which steals life on hit), and found that during the course of a combo, I'd only heal 3 times.

As for your other question about the Hands of Lightning rune, it appears you are getting 3 extra attacks with no damage decrease per attack. I played around with it a bit, and although the damage per hit fluctuated a bit, it seemed to average the same per hit both with and without the rune.

The three attacks each seem to do 1/3 of 140% weapon damage each, so your 5-hit combo is around 9.3% weapon damage per hit, which results in an extra 3 hits giving you another 28% damage.