Does anyone know if this is possible?
I tried changing the "Internet Options" for the computer but it only seems to work on the launcher.
Diablo – Playing Diablo 3 behind a proxy
diablo-3
Related Solutions
Alright, you CANT change the binding of the move/primary/interact and secondary attack (fixed as left and right mouse click). But you can define the action bar buttons as you like - also mouse wheel works.
Key Bindings Overview 
See Actionbar at the bottom, the first 4 buttons refer to Action Bar Skill 1-4 and the last two are the Left and Right Mouseclick (as indicated by the symbol)
You have to enable Elective Mode to be able to place skills wherever you want to, else they are restricted to categories (good for newbies so they always have a somewhat decent skill set active)
In the answers to this question you can see the "-launch" flag which will bypass the launcher update. I've tried it and it at least doesn't break anything, but it may have side effects. It may at least be a stop gap, while you figure out the underlying problem.
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Best Answer
Try using Widecap http://www.widecap.com/ - it's freeware and works fine, not just with games, but with all kind of network software
or
Proxifier http://www.proxifier.com/ - I play many game through it. Everything is ok.
You could also choose one of other proxifiers http://en.wikipedia.org/wiki/Comparison_of_proxifiers