I know Pokemon don't lose Pokerus so much as become unable to spread it but that doesn't make for a streamlined question.
But yeah. I know if I wanna keep the virus nice and contageous, I have to keep the Pokemon in the PC, but I wanna leave the Pokemon in the pelago overnight before I play tomorrow.
So have you done this?
Best Answer
Poképelago is essentially just another way of viewing the pokémon in your PC. That is, there's no way to have a pokémon both be in your PC and not be in poképelago. Therefore, it has no effect on Pokérus.