When you transform into Guppy you get an effect similar to the Mulligan item: when you deal damage, there is some chance of a blue fly spawning. If I become Guppy and get the Mulligan, do they together have a higher chance of spawning blue flies than individually?
Does the Guppy transformation stack with the Mulligan
the-binding-of-isaac-rebirth
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Best Answer
From Rebirth Wikia:
Otherwise, Mulligan "grants an infestation shot with a 1/6 chance of spawning allied blue flies when tears hit an enemy".
So in my opinion they can't stack, because being Guppy already grants a blue attack fly on each hit done.
EDIT:
I know we are talking about Rebirth, but in the previous version of the game, according to the original Wikia:
If they could stack it would mean that you can spawn more than an attack fly, but as the old Wikia states, "you can't spawn two flies with one shot".
In the previous version of the game they didn't stack. And I have no evidence to think they have changed that.