ADR class 6 and class 2 have the highest payout for some types of cargo (ex: acid, which has a price coefficient of 2.20). However, because ADR deliveries only have a single level, they're not the way to make more money. Heavy cargo has (in general) a higher price coefficient than fragile cargo. Since you can increase your % bonus by leveling these up, with Heavy Cargo at level 6 and just-in-time at level 6 (since these combine), you will get the most money going with those skills.
That being said, Fragile cargo has a slightly higher XP bonus than Heavy Cargo (22% vs 18%). So if you're looking to squeeze out more XP rather than money, then you should go Fragile cargo level 6 and Just-in-time level 6. Personally I feel that leveling up is fast enough already, and you'd be better off going for the cash option of Heavy Cargo + JIT.
You'll also want to level up Long Distance, since this will give you reward bonuses that stack with the other skills.
A typical game would look like this for me: Heavy, JIT, Heavy, JIT, Heavy, Long Distance, Heavy, Heavy, Long Distance, Heavy, JIT, JIT, JIT, JIT, Long Distance (up to max). Lastly I'd spend on eco-driving.
Two final tips: When searching for a job, always list by "Price per distance" in order to get the maximum payout per mile. Learn how to park the trailers and never skip parking them manually, so you always get the xp bonus for that.
Any mod that has a game_data.sii file can cause the problem. You only need a small tweak to fix this, that is if you can't find newer versions of your mods. You'll need 7zip.
Mods are loaded in alphabetic order (a-z) so you only need to edit the last mod (to be loaded) that contains the game_data.sii file. So start by opening Realistic Physics Mod. Right-click on it, under the 7-zip sub-menu in the context menu, select open archive. You'll find a folder called def, inside that check for game_data.sii (if you don't find it, skip to the next mod). Right click on it and select edit. Find the following lines
camera_limits_max[4]: (33000.0, 42000.0)
camera_limits_max[5]: (23000.0, 32000.0)
camera_limits_max[6]: (21000.0, 33000.0)
camera_limits_max[7]: (15000.0, 26000.0)
and replace with
camera_limits_max[4]: (45000.0, 42000.0)
camera_limits_max[5]: (43000.0, 32000.0)
camera_limits_max[6]: (34000.0, 33000.0)
camera_limits_max[7]: (15000.0, 26000.0)
save and exit.
Best Answer
No. Console use of any kind does not disable the ability to get achievements, in fact, you can abuse the console to get most of the achievements quite quickly. Mods do not effect achievements either.