Fallout – Does using the Console Commands negatively affect me

Gameplay changes that affect you as you change difficulty from Easy -> Very Hard -> Survival. I have tested most of this in game in a simple way. I've brought my melee character and have quicksaved before a scripted Swan fight. I found out a few things:

• Damage you deal is affected as you progress (Damage dealt is lowered)
  • On Easy, Swans for me were taking 4 light hits to kill.
  • On Hard, Swans for me were taking 20+ light hits to kill.
• Damage you take is affected as you progress
  • On Easy, Swans could hit me for as low as 12% of my total HP. HP values were the same in both tests
  • On Hard, Swans could insta-kill me at times, like the Giants in Skyrim.
• Spawn rate of Legendary enemies (and thusly 'drop' rates of Legendary gear) is affected as you progress from Easy -> Hard
  • On Easy, Legendary spawns are very "hard" (haha) to come by. Legendary gear is infrequently found.
  • On Hard, Legendary spawns just seem a bit more plentiful. Legendary gear is found more often.
• EXP stays the same. Changing the difficulty did not change the EXP rewards from a quest, or from killing an enemy, or from passing a speech check.
• Explosives become a godsend in Survival mode. The damage is heavily amped up and makes dispatching of tougher enemies like AI turrets and Super Mutants a little bit easier

Survival mode is even worse. Consider Survival mode "Extreme" mode. It features extremely tough enemies, as every single enemy gets huge damage and HP buffs, turning them into deadly bullet sponges. Ammo conservation actually becomes a thing in my survival playthrough, and in terms of playstyle, I found hanging back, slowly going through areas, and backtracking if enemies came a lot more useful. Explosives became very important, as well as mines, which were excellent at covering your ass when a Super Mutant is chasing you down a hallway and your entire clip of Laser Rifle ammo does absolutely nothing.

Followers can not die. Also noted in this article about companions that can't die.

Good news: no matter what transpires out there in the wasteland, he cannot die.

In fact, none of the companions that may accompany you on your quest across post-apocalyptic Boston can die. Speaking with IGN, Bethesda's Todd Howard discussed the now-immortal companions, a decision the development team made to better serve the player.

Since they can't die, doubt shooting them will bother them much.