Fallout Shelter – How Can Mr Handy Survive in Fallout Shelter?

The times I have had the need to "off" a dweller I just send them into the waste and let them die there. You will have the option to "remove" them once they are dead.

Just remember to send them out without any outfit or weapon.

Your best bet: Keep your best weapons on people on the uppermost floors, just for raider attacks. If you don't have anyone on the top floor (I have a Vault Door Room and expanded Living Quarters, rarely populated) then you can drag people up from the floor below; keep them armed with the best.

When a localized incident occurs (fires, radroaches), the game should zoom in on the incident room. Simply arm all the people in that room with the best left-over weapons, and as soon as they jump for joy, immediately disarm them. There should only be six of them at any given time so it should never get too out of hand... Assuming you don't send around people with better stats/clothing (I've never seen any reason to do that).

This is assuming that you have people in every room. For otherwise unstaffed rooms, you're going to have to import all of the people from somewhere else. In that case, it is best to drag people over from another room on the same floor, so they don't have to contend with waiting for the elevator. Because of this, try to keep at least one fully staffed expanded room on each floor. So long as they make it there quickly, the incident should not spread; and if they're all coming from the same place, it should be relatively easy to disarm them afterward.