When completing faction/main quests in Fallout 4, you can eventually get to a point where you make a permanent enemy of a particular faction by completing a particular quest for another faction. I'd like to create a saved game where I am at the point where whatever quest I do, I will make an enemy of a faction regardless. The purpose of this is in order to check out all the game endings without having to restart the entire game again.
The question is, which quests for which factions are my stopping points and are there any things I need to be aware of to get to that nexus point? I understand I can't make an enemy of the Minutemen but I can with all the other main factions.
Best Answer
Mass Fusion (/ Spoils of War)
Institute vs. Brotherhood of Steel
Once this mission has started, make your (first) save (see image below)!
End of the Line
Institute vs. Railroad
The player can choose to either warn or kill Desdemona.
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Blind Betrayal
Brotherhood of Steel vs. Railroad
As mentioned on the page for the quest Tactical Thinking:
The Battle of Bunker Hill
Institute vs. Railroad
The infographic below shows how to get as many trophies/achievements in one walkthrough, and thus notes the points at which to make a save game:
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