How does the game prioritize hearts

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If I have white hearts, soul hearts, and normal hearts, in what order will they be taken when I am damaged?

Best Answer

The normal priority excluding the blood machine is soul hearts, then white hearts, then regular hearts.

If you use the blood machine at more than half a regular heart, the priority becomes white hearts, then regular hearts, then soul hearts. At half a heart, it will consume white hearts, then soul hearts, then your last half a heart (killing you). This means if you have a white heart, it will be consumed first on a blood machine - watch out!