To me, Combo and mobility are the two key components to get a high score. Time bonus may seem nice, but its impact on the final score is not as significant as the two others I mentioned. Getting the frog mask makes getting a big combo easier. I usually focus on getting the largest combo possible while refraining from too much use of guns, ignoring how many tries it takes me.
In killings, you simply get points for how you killed your enemy. You get the most points from kills if you are unarmed, and less using melee weapons. Fire-arms do not give a lot of points but they are nice to get a big combo. Exotic weaponry such as the drill gives the most.
Boldness should be how reckless you are. If you put yourself in dangerous situations where the enemies try to attack or shoot you, boldness goes up. I am not completely sure about this though. Use of firearms can have a direct negative impact on your boldness score.
Mobility drops if you are staying put all the time, waiting at doors and behind corners. Moving about from room to room without stopping ensures a high mobility score.
Flexibility is supposed to be how you make use of the weapons available to you. If you kill every person on a floor with fists only, you get a high killing score but low flexibility. Constantly changing weapons from what's available improves flexibility. If you are never getting any flexibility, you may need to patch your game.
When you manage to clear an entire floor in a single flowing combo, you are pretty much guaranteed the A+ rating.
Another way to get very high scores is to use non-standard weapons such as the drill which gives 5600 points per kill.
Edit: The points awarded from Drill-kills have been reduced to ~1000 points in the latest version.
You must collect every little purple block (as Berg mentioned in their answer) in chapters 1 - 16. I detailed where every piece is in this answer. When you collect them all, you must align them in the "Puzzle". When a piece is in the correct space, it will start glowing. The final result is:
IWASBORNINTHEUSA
This will end up unlocking different dialog (a secret ending) at the end of Chapter 19, if you examine the computer before taking the ladder down.
Best Answer
There are in fact multiple ways to complete this section of the level. The actual goal is to reach the lift on the far right hand side.
The first way is to grab the keycard, as mentioned in this answer, which opens the locked door directly opposite, allowing you to proceed. This route is marked in red on the screenshot below.
The second way is to head down the corridor directly to the lift, being careful to avoid being spotted by the wandering nurses/doctors. This route is marked in orange on the screenshot below.
If you're having difficulty on this level, one thing to note that might help, is that the cops only notice you when they're not reading; so make sure you only go into their line of sight when their newspapers are up (I completely failed to notice this the first time I tried this level).