How to take a screenshot in SimCity

Assuming windows 7, you should already have a shortcut available in your windows Games folder. For me, this is located at C:\ProgramData\Microsoft\Windows\Start Menu\Programs\Games.

Alternatively, if you hit the start button (or windows key) and type "games explorer" and open the folder it displays, it will list all your registered games. .

From either of these folders, you should be able to right-click-drag the game's icon onto the desktop, and selecting either copy here (games folder) or create shortcuts here (games explorer)

You will need an Origin account and be online in order to start the game. Once playing, you will be able to disconnect from the internet and continue playing in offline mode.

Source

Edit:

Unfortunately, you won't be able to play for long periods of time in this way. This Digital Trends Article says:

Maxis responded that players who lose their connection mid-game will be allowed “to play for as long as we can preserve your game state” a period that will “likely be minutes.”

So it appears that the answer is no, any offline play would only be possible to preserve your game during a temporary disconnect.