Please keep your answer spoiler free, I am curious if there is any lock-out content when you progress a certain amount. For example can you get locked out of side quests and content by progressing through the main storyline first? I'm sort of burned out on the idea of being a completionist.
The Witcher 3 – Is There Lock-Out Content in the Witcher 3 Expansions Due to Completion of Main Questline?
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Best Answer
Heart of Stone has a single main quest line. There are some different relatively minor options you can make in the main quest, but the side quests are unrelated and will not disappear.
As a light warning, during the wedding party segment of the main quest line, there are some optional activities which will become inaccessible if you progress the main objective. These activities are mostly humourous scenes more than anything else.
Blood and Wine covers a large new map structured similarly to Velen. There are a great many side quests, and I can't promise you the main quest's completion won't lock any out, however it would be few if any.
The very end of this DLC's main quest has two completely different paths to the finale, and three possible endings from there. There is a point of no return warning before this begins, however unrelated quests are still available after the finale.
Original answer, from the perspective of the core game's main quest: