Is it possible for Muramana's active to proc twice on one single-target attack? For example, Poppy's Devastating Blow (Q) or Twisted Fate's Pick a Card (W) add an effect to the following autoattack. On the next autoattack, the spell is used and on-hit effects are applied. Do these abilities, or any other ability, allow Muramana to activate twice?
League-of-legends – Can Muramana’s active ever proc twice on one attack
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Best Answer
While certain abilities (like Draven's Spinning Axe, Mordekaiser's Mace of Spades, or Twisted Fate's Pick a Card) modify your auto-attack, their effect triggers as part of the auto-attack, not as an additional effect.
Therefore, Muramana does not trigger once for the ability AND once for the auto-attack, because, for these abilities, the auto-attack is the ability.
Likewise, abilities that cause on-hit effects (such as Ezreal's Mystic Shot or Gangplank's Parrrley) only trigger Muramana once. Abilities that cause multiple on-hit effects (such as Warwick's Infinite Duress) trigger Muramana once per "hit", but do not get an additional trigger from the fact that it is a single-target spell.