What is the best Heavy Weapon to use in general in Mass Effect 2? The Cain nuke launcher is pretty funny, but it's not worth using because of how much ammo it requires. In general, I use the Collector Particle Beam or the Grenade launcher. I find the Avalanche and Missile Launcher to not be as effective.
What's the best to use overall without switching?
Best Answer
The Collector Particle Beam has many advantages over other heavy weapons:
It also has a +50% bonus against both armor and shields.
The main downside is you're out in the open while firing, but most of the time I feel the advantages outweigh the risks.