Minecraft Mods – Can Different Mods Be Used in Different Worlds?

Get and use MagicLauncher instead of the vanilla Minecraft launcher, and use its "profile" manager to set up one profile with mods for single-player and another profile without mods for multiplayer.

Because it loads mods dynamically, you don't have to alter the minecraft.jar, leaving you a perfectly-vanilla game for multiplayer. In your single-player profile's setup just add the mods to the lists of internal and external mods, and the launcher will add them to Minecraft only when you start the game with the single-player profile. When you want to play online, quit and restart to login with the vanilla, multiplayer profile.

If you are using the latest vanilla launcher:

1. Create or edit a profile
2. Check the box labeled "Game Directory" and fill in a location to put it. It will automatically create the directory if it doesn't exist on next launch of the profile. (Note that I doubt it will expand shell variables, but it works just fine with symbolic links if you use those)
3. Click Save Profile

What I have done for this is I have created a directory under my $HOME called .minecraftProfiles and I put each separate profile in its own subdirectory. For example, vanilla 1.7.4 I have put at homedir/.minecraftProfiles/1.7.4-vanilla.

Sharing data between profiles:

• If and when I want to share a file and keep it shared (for better or for worse) I would symlink to it from one profile in the other(s).
• If I want to use some data (saves and such) as a basis for a new profile, I first copy the directory to a new one, create the new profile in the launcher (click "New Profile" when the one I'm copying is the selected profile), and after starting up that profile, (if necessary) do manual editing of the $HOME/.minecraft/versions/profilename/profilename.json when it is needed to have it actually keep some necessary data (if same version of Minecraft and wanting to keep Forge, for example)

Tips to avoid issues with losing valuable data:

• Keep multiple profiles in separate directories to avoid conflicting mods or mod configurations.
• Each profile should have a specific version set for the "Use version" under "Version Selection" in the Profile Editor to prevent it automatically updating and preventing you from playing on servers that haven't updated.
• Backup, backup, backup - before adding/removing mods, changing the version of a profile, and especially regular backups just in case your computer (or just Minecraft) crashes.

If you are not using the vanilla launcher (read: FTB / Technic launchers), all I can say with 100% reliability is you would have to either use a separate user account (for Linux, which you should be for different people anyways according to many Linux security specialists) or deal with moving the storage location of those launchers manually each time before starting.

(partially off topic) I choose to use a naming scheme of version-info for the naming of my profiles' directories, but you can opt for adding the user's name at the beginning of it.