Typically, only special rooms are marked on the map (item rooms, shops, arcades, bosses, deadly sins, etc.).
What's special about the blood room shown below? I tried hurting myself on the spikes, and nothing happened.
Nything special about the blood rooms
the-binding-of-isaacwrath-of-the-lamb
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Best Answer
If you damage yourself some inconsistent number of times on the spikes in the room, a chest appears.