I've recently picked up Uncharted: Drake's Fortune from the Amazon "bargain bin" and have been playing through it. Quite a fun game, actually, but I've only managed to get to Chapter 10 ("The Customs House"). The chapter's opening cutscene finished and I started to run towards the stairs inside the customs house when the game locked up completely. No PS menu key response, no Start response, etc. The PS3 required a full restart.
So I ejected the disc, buffed it for fingerprints (negative), examined it for scratches (negative) and loaded up again thinking that the glitch was perhaps temporary. No such luck. This time, the game loaded me in post-cutscene and I managed to get a few steps up the stairs before it froze again. Same effect, same remedy. I tried a third time, got to the room at the top of the stairs, and POOF, another freeze.
Help?
Best Answer
I found an answer (or maybe "work-around" better describes it). I tried the suggestion jwaddell made and was still encountering the freezes. Working off a suggestion I saw on the official Playstation forums, I disabled subtitles and game hints from the Options menu. I also had been running straight up the stairs and looking to the left (you see a murder of crows sitting on the floor if you look left).
So, with subtitles and game hints disabled, I ran halfway up the stairs, pulled out my AK-47 and strafed up facing right. Lo and behold, there was a shotgun MOB waiting for me. I dispatched him with a well-placed headshot and then moved out through the doorway. No freeze!
I am not sure whether the freezing was triggered by the subtitles, the game hints, or glitchy AI becoming over-excited at the prospect of shooting me in the back of the head unawares. In any event, I'm now past the customs house, have re-enabled game hints and subtitles and am mercifully freeze-free thus far.