Regularly changing Skyrim difficulty

According to the UESP, the difficulty level affects the damage you deal and the damage you receive:

Difficulty | Damage Dealt | Damage Taken
-----------------------------------------
Novice     | x2           | x0.5
Apprentice | x1.5         | x0.75
Adept      | x1           | x1
Expert     | x0.75        | x1.5
Master     | x0.5         | x2
Legendary  | x0.25        | x3

Based on this, there are a few things you can extrapolate as the difficulty level increases:

• Skills based on damage increase more slowly, and in turn, the slower you level up (thanks yx.)
• Followers can be knocked out, and in turn, killed, more easily
• Your effective health decreases
• Enemies' effective health increases

Possible note: Weapon Skills aren't based on final damage; they are based on base damage of the weapon, which is unaffected by difficulty. Increasing the difficulty means that you have to hit each enemy more times, which speeds up skill growth. This is very noticeable when you increase the difficulty as my one-handed increased about 6 levels after 2 dungeons.

Since you can't use the developer console it might very well be unsolvable, but they might correct it in a new patch.

Few ideas I've got:

• Try to become a vampire, when you are standing in sunlight, all your attributes get permanently (until it is night or you are indoors) decreased, the magnitude depends on which stage you are.

• There is an effect, accessible only by using alchemy, that permanently lowers health. It is not the damage one, but Ravage should do it (if I understand it correctly). Although I don't really know whether the potions you create with both positive and negative effects are classified as potions or poisons.

Both of these effects are reversible and might very well not be of any good, but you can at least try.
I am sorry I couldn't provide anything better.