Is it possible to play the PC version of Left 4 Dead 2 in split-screen, where one player uses the mouse/keyboard and the other uses a gamepad?
Split-screen in Left 4 Dead 2
left-4-dead-2pc
Related Solutions
It is now possible to play old mutations; when you select Mutation, the last option in the menu is "Change Mutation," and there's a pretty good list of Mutations you can play, in 1-, 4-, or 8-player games.
Note that, because there are a couple of dozen available mutations (counting all modes), it can be hard to get a game going unless you're willing to wait a while or invite some friends. If you want to play soon, invite friends or get used to bots. ("Four Swordsmen" is awful with bots, by the way. If you get grabbed by a Smoker on a ledge, your teammates can't figure out how to get to his ledge and stab him.)
The safest place, by definition is the safe room.
Other safe places are rooms with doors closed, of course until infected destroy them. And in general all places that can have only few entrances (one or two) so that they can be easily guarded by your team mates. Trucks, garages, rooms and so on.
If you are instead searching places where infected cannot reach you, they probably go under definition of maps bugs/exploits. Because for sure map designer/developers do not want to add places where you can safely stay without being reached by infected.
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Best Answer
Yes, you can. You have to make sure you know your way around the console, and playing online might or might not work.
Basically, you have to enter these commands in the console to make it work:
You have to make sure your Xbox 360 controller is set up correctly, for that, read this forum post: Left 4 Dead: SplitScreen PC Guide.
It's possible play split screen with a non-Xbox 360 controller, but you'll need to set up your own controller configurations by editing edit \left4dead\cfg\360controller.cfg. The lines you'll need to edit are the ones starting with "cmd2 bind".