I just used a pill and received the message "Luck Down." I'm aware of Faith, which increases your chances of finding the Bible, and I suspect this is similar.
What is Luck?
The stat ‘Luck’
the-binding-of-isaacwrath-of-the-lamb
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Best Answer
Luck is a stat that will increase the "level" of items that you find and your gambling output. For example, when you have the "Luck Foot" that Cain starts with, you cannot get "bad" pills such as bad trip, speed down, and other such bad effects. You can however get neutral and good pills like "Bad Gas", or Health up. I don't recall if Explosive Diarrhea is considered bad or neutral. You also get many more "victories" when playing blood banks, the shell game, and slot machines.