What happens if I leave Worms intact after destroying Alien Nests? I would expect that no more Biters and Spitters will be produced, but will leaving the Worms there cause any problems for my base?
factorio – What Happens to Worms Left Alive After Destroying Nearby Nests in Factorio?
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Best Answer
Worms cannot move - think of them as turrets but for the Aliens. Unless you eventually expand your base towards the Worms you left alive, they cannot do anything more to you. Worms are only created during enemy expansion according to the Factorio Wiki:
So leaving the Worms should be fine, but if you leave Biters and Spitters, they will go off and create new bases eventually, thus leaving any Biters and Spitters alive after destroying their base allows them to repopulate. It is probably difficult to do so though as Biters and Spitters will attack the player when you engage one of their nests, which essentially forces you to have to kill them or be killed. During the expansion process however, when the individual Biter/Spitter dies, it either turns into a new nest or a worm.
From the Factorio Wiki: