What’s better for a Berserker? Howl or Battle Rage

How to Activate the Console Window

• Alter the file “settings.txt” found in your Torchlight 2 Save file.
• The save file is found here: %userprofile%\My Documents\My Games\Runic Games\Torchlight 2\save (There's a subfolder in there which is just a bunch of numbers, and in that subfolder is your settings.txt file, along with all of your saved games)
• Open the file with a text editor, then press Ctrl+F and search for Console :0. Change the parameter from Console :0 to Console :1 to activate the Developer Console, enabling use of cheat console commands in Torchlight 2.
• Now that console is activated, you can open the Console window while in-game by pressing Insert.

NOTE : Using the DEV CONSOLE risks having your account marked as suspicious to unmodified players of Torchlight 2 online. Use console commands at your own risk.

Source: GameFront

This doesn't answer your question per se, but I think you may find it helpful:

If you hold down the Shift key, clicks will always attack rather than moving; attacks will be aimed in the direction of the cursor. I don't know whether they lock onto mobs if you specifically click on one, but I've never had any trouble playing this way, using Shift to “plant my feet” whenever I'm not moving.

If I recall correctly (I haven't been playing recently), there's also a few breakable objects which cannot be targeted, so can only be broken this way.