Deus Ex: Human Revolution gives you three options for starting a new game, "Tell Me a Story", "Give Me a Challenge", and "Give Me Deus Ex":
The wording seems to imply that there's more difference than just tougher enemies (i.e. more/less emphasis on story), is there?
Best Answer
No. "Tell me a story" does not mean that the story is enhanced. Rather, it means that the challenge is decreased, as if to say that the game is only interesting for its story and not its gameplay challenge if the player picks the reduced difficulty.
To be specific, harder difficulty decreases your health and regeneration rate, increases the enemy's health, regeneration rate and accuracy. It also affects the regeneration delay. (Source: GameFAQs)