When is an item removed from its Item Pool

the-binding-of-isaac-rebirth

I want to do a Jera + Blank Card break.
I've found the Blank Card in a Basement shop but I hadn't enough coins to buy it, so I had to leave it there.

Anyway I've started generating several chests with D20 + Sharp Plug and I've already exhausted the Golden Chest item pool, I'm finally getting Tresure Room items.

So I'm wondering: can I still find the Blank Card if I've already seen it (and not bought) in a shop?

Best Answer

The answer is: YES.
You can find an item you've only seen in the shop again. So, seeing (not buying!) an item does not remove it from the Item Pool.

I've just generated the Blank Card that I was looking for, here's the proof:

Black card found!