As far as I can tell, this is an unused sprite. The doors that would have those letters are most often letter-less. If anything they have two overlapping squares:
Controller inputs are only associated with tetrominos once.
Where?
Towards the top of the map, in the tree near the octopus building that houses the solar system model.
What's inside?
A puzzle that displays tetromino blocks based off of controller inputs, and an anticube prize for cracking the nearby pillar's code. (image) (link to finished cipher)
The classroom in the 8-cube Blade Runner city then shows how to interpret the pillars with tetromino inscriptions. Here's one wall, but relate it to the others:
Numbers cipher
Like the alphabet, there isn't one proper way to do this, but you might be interested in the 16-cube temple's classroom. Instead of trekking back, this is what it looks like:
Hint:
Those are "equals" signs, and the last picture is arithmetic. Also, the figure/ground is confusing—pay attention to the box and its internal vertical/horizontal lines, not the "C" shapes. (link to finished cipher)
Best Answer
As far as I can tell, this is an unused sprite. The doors that would have those letters are most often letter-less. If anything they have two overlapping squares: