Yes (probably)
Rules as Written, I think you can kill the 0-hit-point Misty Vampire by doing damage to it three times before it escapes to its resting place, or by doing massive damage to it (equal to or exceeding its maximum hit points).
But there is certainly room for disagreement, as the rules regarding creatures with 0 hit points are written in the context of creatures that are unconscious at 0 hit points, which the Misty form of the Vampire is not.
Honestly, I don't think the intent of the rules is to allow a Vampire to be destroyed in this way. It seems that the intent is that you have to follow it back to its resting place, drive a stake through its heart, and then destroy its body while it's paralyzed.
Rules around having Zero Hit Points
PHB p. 197 says
When you drop to 0 hit points, you either die outright or become unconscious....
Creatures that take massive damage die outright.
Otherwise they fall unconscious but are dying -- they must make death saves to determine if they eventually stabilize or die outright.
There are three exceptions wherein a creature may be stable at 0 hit points -- still unconscious, but not needing to make death throws.
- If the attacker decided to strike an incapacitating blow rather than a fatal one to take the creature down to 0 hit points [PHB p. 198]
- If the creature is stabilized by another creature (by making a medicine check [PHB p. 197], using a Healer's kit [PHB p. 151], or by using the Spare the Dying cantrip)
- If the creature stabilizes by rolling three successful death saving throws before rolling three failed ones.
Note that in all cases here, a creature with 0 hit points is unconscious.
Normally there is no way for a creature to be at 0 hit points and still be conscious and taking actions. However, the Vampire is clearly an exception, based on the text of its Misty Escape feature. It is very unclear whether any of the usual rules that apply to unconscious creatures at 0 hit points also apply to Misty Vampires at 0 hit points.
So What Rules Apply to a Misty Vampire that is Stable and Conscious at Zero Hit Points?
The description of the Vampire clearly admits the possibility of doing damage to the Misty Form by magical means.
Taking Damage at 0 Hit Points (PHB p. 197):
If you take any damage while you have 0 hit points, you suffer a death saving throw failure. If the damage equals or exceeds your hit point maximum, you suffer instant death.
And:
On your third [death saving throw] failure you die.
Note that a creature that takes damage while at 0 hit points that isn't enough to kill it outright remains at 0 hit points. 5e does not have a concept of negative hit points.
Two Ways to Kill the Zero-HP Vampire (RAW):
1) damage it three times, causing it to fail three death saving throws before it has a chance to stabilize or be stabilized by any of the means listed above
2) damage it once, for an amount that equals or exceeds its maximum hit points (perhaps a massive Paladin critical smite)
Caveats
- If the Vampire has not used up its Legendary Resistances for the day, it can choose to succeed on its first three death saving throws, so you would have to hit it additional times to get three failed death saves that "stick".
- It is very unclear whether any of the usual rules that apply to unconscious creatures taking damage at 0 hit points are also meant to apply to conscious Vampires in Misty form at 0 hit points (but RAW I believe there is nothing to override them).
- It is possible that the Vampire's Misty Escape kicks back in and stabilizes the Vampire every time it gets hit, removing method 1 as a possibility (but I don't think so, see below).
- It is possible that Vampires are meant to be immune to failed death saving throws (but I don't think so, see below).
On Misty Escape Re-stabilizing the Vampire
Clearly when the Vampire first drops to 0 hit points, the Misty Escape feature permits it to be stable and conscious where ordinarily it would be neither of those things.
If the Misty Escape feature triggers each time the Vampire takes damage while at 0 hit points, it could be argued that the feature stabilizes the Vampire each time.
However, the trigger for Misty Escape is that the Vampire drops to 0 hit points (outside its resting place). Getting hit while already at 0 hit points and remaining at 0 hit points does not constitute dropping to 0 hit points.
On Immunity to Failed Death Saving Throws
PHB. p. 198 says that Monsters can sometimes make Death Saving Throws:
Monsters and Death:
Most DMs have a monster die the instant it drops to 0 hit points, rather than having it fall unconscious and make death saving throws.
Mighty villains and special nonplayer characters are common exceptions; the DM may have them fall unconscious and follow the same rules as player characters.
Note that this is given as an option for a DM to make a creature more powerful than a normal monster that just drops dead at 0 hit points. But we already know that a Vampire is not a normal monster that just drops dead at 0 hit points. Its Misty Escape feature is a stronger feature than the standard Death Saves feature that prevents PCs from just dropping dead at 0 hit points. So this clause in the PHB doesn't really apply in this case.
However, I don't see anything here to suggest, whether the DM usually gives monsters death saves or not, that any monster should be immune to dying after suffering three failed death saves at 0 hit points.
Vampires are "chained to the grave"
As clarified in the earlier descriptive text at the start of the Monster Manual entry on vampires (p. 295), vampires and vampire spawn are bound to their sites of burial or entombment:
Chained to the Grave. Every vampire remains bound to its coffin, crypt, or grave site, where it must rest by day. If a vampire didn’t receive a formal burial, it must lie beneath a foot of earth at the place of its transition to undeath. A vampire can move its place of burial by transporting its coffin or a significant amount of grave dirt to another location. Some vampires set up multiple resting places this way.
The vampire's grave site and burial are metaphysically significant to their nature - a vampire cannot exist without a grave of some kind that acts as its resting place, from which it ventures at night and returns to during the day. A creature killed by a vampire's bite who does not receive a deliberate burial will not become a vampire spawn unless "naturally" buried somehow - such as by a landslide or cave-in. Either way, they must be in conditions that could be described as a grave or tomb in order to raise as a vampire.
The "Stake to the Heart" weakness that vampires and vampire spawn have specifically references their resting place:
Vampire Weaknesses. The vampire has the following flaws:
[...]
- Stake to the Heart. If a piercing weapon made of wood is driven into the vampire's heart while the vampire is incapacitated in its resting place, the vampire is paralyzed until the stake is removed.
And the vampire spawn version:
- Stake to the Heart. The vampire is destroyed if a piercing weapon made of wood is driven into its heart while it is incapacitated in its resting place.
Vampire spawn, though less powerful than "true" vampires and slaved to their master's will, are still vampires with normal vampiric strengths and weaknesses, and they still require a grave of some kind to rest in.
Best Answer
A Mace of Disruption can kill a vampire outright.
You've already quoted and stated the most relevant details.
The Mace of Disruption says:
While the vampire's Misty Escape ability states:
The Mace of Disruption's effect doesn't simply drop a creature to 0 HP, it flat-out destroys them if they have 25 hit points or fewer after taking the damage and fail their wisdom saving throw.
Therefore even if the damage from the attack drops the vampire to 0 HP and it transforms into a cloud of mist it's still destroyed since the vampire's mist form doesn't grant it any kind of immunity to magical effects or being destroyed.