I have over the past couple months been putting together Ideas on how I would run an All Flesh Must Be Eaten campaign. How do other DMs organize their Bads or Locations that the PC's might wish to frequent?
My initial Ideas are to go mega-man style, giving them the options of all the "Generals:" Just plopping down a big map of the area and saying "You eventually want to be here, but it's up to you how you want to get there." Then have certain events would happen at certain places with "The big bad" of the area and however many "Minions" required, depending on how the party "Levels up" throughout the campaign. I think I would keep track of it all via a labeled binder with all the general locales, crudely drawn map, Big boss info, and the general stats of bad guys.
Best Answer
I almost invariably run sandbox games, what the players do is entirely up to them and the plot advances through NPCs no matter if they interact or not!
Before organising a big sandbox campaign where there are strategic targets I'd advise the following:
Getting to the location.
If they can't find out about the location, how can they shoot/bite/run away from it?
Where do you put them?
There are several ways you can do "where is the big bad" depending on the type of campaign you want to run.