[RPG] Does the Crossbow Expert feat’s extra crossbow attack work with the reaction attack from a Hunter ranger’s Giant Killer feature

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I'm planning on making a Goblin Ranger (Hunter subclass). I was reading over the Hunter ranger's Giant Killer option at 3rd level:

When a Large or larger creature within 5 feet of you hits or misses you with an attack, you can use your reaction to attack that creature immediately after its attack, provided that you can see the creature.

My ranger would have the Crossbow Expert feat (PHB, p. 165), one of the benefits of which is:

When you use the Attack action and attack with a one-handed weapon, you can use a bonus action to attack with a hand crossbow you are holding.

If I used my reaction to strike back against a human who missed an attack against me, would my feat also trigger a follow up attack of my hand crossbow?

Best Answer

No, for at least two reasons.

Crossbow Expert (PHB, p. 165) is very specific about when you can make an attack with your hand crossbow:

When you use the Attack action and attack with a one-handed weapon, you can use a bonus action to attack with a hand crossbow you are holding.

You are using a reaction to make a single attack; you are not taking the Attack action.

Also, your Giant Killer feature does not apply to humans:

When a Large or larger creature within 5 feet of you hits or misses you

Humans are Medium-sized. As the name implies, you can only strike back against big creatures! (Sized Large, Huge, or Gargantuan.)