As a fallback against them coming back once they're dead you can always try a wish spell to stop them coming back once you've killed them.
However, if it is True Resurrection that is bringing them back, there is a gotcha;
Even true resurrection can’t restore to life a creature who has died of old age.
Now given that these are Drow anyway this is a bit of a long time to take into consideration; but you could get them by:
- Kill 'em
- True Resurrect them (so they are now alive, not undead)
- Age them a lot** (Find/Summon a monster that does aging damage and get it to attack them)
- Watch them die of old age.
- Do a "ding dong the Drow is dead" dance.
** Level draining may work as well here, but I don't think it's as surefire a method.
As an additional thought; you could possibly reincarnate them instead, they will be reasonably likely to come back as a somewhat less long-lived race than a Drow and then make them die of old age. They'll still have died of old age then! However you'd have to true resurrect then, kill them, then reincarnate them as reincarnate doesn't work on undead, this might be getting a little complicated ;)
Yes.
The template lists all weaknesses of Vampires:
Weaknesses: Vampires cannot tolerate the strong odor of garlic and will not enter an area laced with it. Similarly, they recoil from mirrors or strongly presented holy symbols. These things don't harm the vampire—they merely keep it at bay. A recoiling vampire must stay at least 5 feet away from the mirror or holy symbol and cannot touch or make melee attacks against that creature. Holding a vampire at bay takes a standard action. After 1 round, a vampire can overcome its revulsion of the object and function normally each round it makes a DC 25 Will save.
Vampires cannot enter a private home or dwelling unless invited in by someone with the authority to do so.
[...] (exposure) to direct sunlight, [...] immersion in running water, [...] wooden stake through [the] heart [...]
Assuming your temple is not laced with garlic and is not a private home (or inside a private home), the most troublesome part are holy symbols.
Seeing that it takes a standard action to repel a vampire using a holy symbol, "strongly presented" seems to refer solely to characters or NPCs "strongly presenting" their holy symbol, as in the description of Channel Energy:
A cleric must be able to present her holy symbol to use this ability.
Arguably though, holy symbols in a temple are "strongly presented", they are usually central to the whole design (think of crosses in christian churches).
(Personally, I'd rule the latter case, because I don't like the idea of vampires walking in the front door of a Sarenrae temple, but commoner with a carved holy symbol can repel him...)
In any case, the weakness does not pertain to unholy symbols, so your bad guy is good to go.
Typical area spells found in evil temples of doom also don't hinder vampires. In fact, a vampire benefits from desecrate the same way all undead do. Unhallow also has no special effect that prevents a vampire from entering. As Jeor Mattan points out, not even hallow can prevent Vampires from walking in the front door.
Best Answer
Yes, but it's very unlikely.
Trying to hit a specific location on a creature requires the variant rules for called shots (Ultimate Combat p.193). Which even specify how they interact with vampires and cyclopses.
So it's theoretically possible, but you have to pass all of the following criteria: