If someone is depressed you can say, "We knew about his depression." How about the feeling of meaninglessness? I think you can't say, "We knew about his meaninglessness" (since it's not a state or condition).
Learn English – Word for the state/condition of feeling that one’s life is meaningless
single-word-requests
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Best Answer
Do you have angst, ennui, or weltschmerz?
I'd guess ennui. From the OED:
Example: