Diablo – How does Epiphany affect skills

Using the Skill Calculator, here's what I came up with. I've broken it up at every ten levels, to try to limit what's available.

Level 10: Skills

• Fists of Thunder with Thunderclap rune; fastest single target attack, with teleport to speed up travel time, too.
• Lashing Tail Kick with Vulture Claw Kick rune; AOE damage with Fire.
• Blinding Flash; to blind and allow some free kills.
• Dashing Strike; to get into the middle of a pack and use Lashing Tail Kick for quick damage.
• There is no passive at level 10 that directly add damage. Resolve, however, will reduce enemy damage, allowing you to do more killing before needing to back off and heal.

Level 20: Skills

• Crippling Wave is slower than Fists of Thunder. This is the AoE option, with Mangle rune; for single target damage, Way of the Hundred Fists is probably better. Without knowing how fast each skill is, though, there is no way of knowing for sure.
• Wave of Light with Wall of Light rune; if you can manage to line up your enemies to hit a lot of them, this will do lots the bell drops on, and a bit of collateral damage to the enemies behind.
• Blinding Flash with Blinded and Confused rune; none of the defensive skills do damage, but with the rune, there's a chance of getting a little monster action helping you out.
• Exploding Palm with The Flesh is Weak rune; a great skill to finish enemies in a mob off with; they'll explode and deal damage around them.
• This is a toss-up between Cyclone Strike and Seven-Sided Strike. Single target damage is absolutely Seven-Sided Strike. AoE, though, depends on how many enemies are around; if there's 8 or more, Cyclone Stike will deal more damage overall.
• Mantra of Evasion; the only mantra available at level 20.
• Transcendance; keeps you going by using your Spirit.
• Exalted Soul; increases your maximum Spirit, allowing you to use more techniques, and get healed more in the process.

Level 30: Skills

• Way of the Hundred Fists with Hands of Lightning rune; if I'm reading the tooltip correctly, the rune should push the damage from 140% to 200%, based on 20% per hit. As a primary single target attack, I don't think that can be beat.
• Crippling Wave with Mangle is still the AoE attack of choice.
• Wave of Light with Explosive Light rune; drop the bell and make it explode!
• Serenity with Reap What is Sown rune; best used for single target attacking in the middle of a group of mobs; it'll blow up and do lots of damage when it wears off.
• Sweeping Wind with Master of Wind rune; this, right here, will be the go-to skill for AoE in large mobs for Monks. Just keep up killing, and this will continue to help out.
• For single target damage, Seven-Sided Strike with Sudden Assault rune will rule. For AoE, it's still a tossup; Cyclone Strike with Implosion rune will do incredibly well in large groups.
• Mantra of Conviction; straight up 12% damage boost. Mantra of Retribution with Retaliation rune, though, would probably beat it if you're in the middle of mobs and you have low armor.
• None of the passives from level 20 to 30 increase damage. I added Chant of Resonance to increase Mantra lifespan.

As you can see, it's extremely situational. What skills will work best differs depending on your situation. Hang back, act as support? Single target is probably your best bet. Attempt to imitate a Barbarian and charge in? AoE's your man.

Yes. As long as you're chaining these "combo" moves together without interrupting using a non-combo move, the hits will continue to count up even if you switch which specific skill you're using.

A really good choice appears to be to use Way of the Hundred Fists as your second strike, since the second strike of that one hits multiple times but the other ones do not.