Diablo – How to turn off the loot message

As of a recent beta patch, runes are no longer items that are dropped. Instead they are basically skill modifiers that are unlocked as you level up. Each time you level up, you will unlock new skills and/or rune choices that affect your existing skills. You choose a certain number of skills, and a corresponding rune for each, to equip as your skill set. Each skill can have up to 6 different rune versions of it, but you must select which one you want to have equipped at any time. There are no longer different levels of rune abilities, it is simply a matter of having it unlocked or not.

Waiting for an ideal random placement is part of it (I was fortunate enough to have 4 prisoners located nearly adjacent to each other. A pity it took me so long to find them!), but the other thing is that you don't have to kill everything on your way.

Speed is of the essence, so skip combat when you can. Abuse the crap outta Dashing Strike and/or Tempest Rush (You're playing a Monk, right?) (Or whatever movement skill your class has) to get in, get out, and keep going.

And lastly, don't give up if it takes a few goes. One run the random numbers will fall into your favor, and then you'll get it in the end.