It's clear that key farming will be an exercise on its own, but after key farming, what strategies are effective in farming the organs?
For example in Diablo 2 it was well known that you wanted to wait to open all 3 portals at the same time to take the randomness out of it, is that possible in Diablo 3?
Best Answer
I just did 3 complete sets last night with my friends and here are some general tips to do this.
Depending on your dps, you may want to prepare some champions/elites near waypoints to 'restock' up on NV in between boss fights. Since you NEED to maintain 5 stacks for any chance of the organ drop at all.
You'll want to fight on the highest MP you can tolerate at since each additional level grants a 10% chance of dropping an organ.
You can open up all 3 portals at the same time, you don't have to worry about portal placement like in d2 (raise your hand if you've borked yourself like I did by opening up 2 portals at the same place in D2), each portal shows up in a prearranged position. They are arranged in a triangle. When you use the inferno machine in the shack, one random portal will open up in one of the locations. I recommend just opening 1 at a time though, in case you can't handle the boss on that MP or if the game crashes, so you don't waste 3 inferno machines.
Specific portal boss strategies:
Remember, these are considered full boss fights. Don't hit that resurrect button (if you are playing with friends) as you'll be kicked out of the battle. Try to get a res if possible.