Roaming has become a popular addition to the metagame strategy, wherein one player does not lane nor jungle, but rather simply moves through the jungle/river to initiate ganks on lanes from level 1 and onward, until the teamfight portion of the game begins.
A roamer essentially guarantees that you're either running a solo lane, or two solo lanes if you have a roamer and a jungler. I've also seen a double roamer game played, though this tends to be less effective as enemies who are wise start playing defensively and reduce the effectiveness of your roamers, which put them behind in both CS and levels.
The qualities of a roamer can vary, but the general requirements are that they are mobile, can do burst damage, and have a strong stun or position altering (push, throw, etc.) ability. Taric, Evelynn and Alistar are all very popular choices for roaming. I've also seen Sion and Blitz play roaming effectively, but they were both out of a lack of a jungle spot on the team and normally suit better in a lane.
This strategy is similar to the "double jungle" mindset in that you get three solo lanes, with the exception that there is extra pressure on getting early kills to succeed. A definite risk vs. reward tossup, as successful roamers will quickly catapult your laners ahead in level / CS as well as demoralize your opponents, but unsuccessful roamers will fall just as far behind due to the lack of their presence in the laning phase.
Many of the settings can be changed manually if you know what you're doing in the game files, but unfortunately a lot of these are not supported to be changed from anywhere except from within a game. In fact, some of them are not even supported in there, and MUST be changed manually!
The official wiki has a multitude of examples listed here
You can always start a Custom Game with no penalty for leaving, and without requiring other people to be in game. You may choose to add bots as well to mess around with settings that may depend on seeing enemies and teammates (such as the side indicators for teammates, and the Tab overview screen).
Note that Custom is different than Co-Op vs. AI.
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In the tray open the volume mixer by clicking on the volume icon and selecting "mixer". Using this you can mute specific programs/games.