Mass-effect – What does the blue cross signify

Firstly for an initial point of no return - as soon as you get access to the Sirta vendor in the Hospital ward buy a/the present/s, completing missions removes them quickly before you know their value.

Secondly before beginning Priority: Tuchanka you should finish off as many sidequests as you can, since completing it renders some sidequests as failed. Don't panic about having some remaining in your journal however, a few don't have their locations unlocked for retrieving quest items until later.

Thirdly Priority: Cerberus Headquarters is the point of no return for the rest of the sidequests. You can still use the onboard vendors on the normandy to purchase goods, but because of the price markup on the ship it's better to visit them directly for whatever you need before commencing this mission as well.

A lot of this is dependent on class. As a Vanguard for example, you'll probably never want to use an Assault Rifle - they're just too heavy, and as a Soldier, you'll usually give SMG's a pass - everything they can do an AR does better. Meanwhile, an Infiltrator gets lots of bonuses when using their trusty Sniper Rifle, evening if irresponsibly shooting it from the hip.

The second consideration is range: at very long ranges, a Sniper Rifle offers top notch accuracy. AR's and Pistols Can be pretty good. SMG's can be flaky though, and shotguns are nigh useless. By contrast, Shotgubs ate devastating at short range, but the loss of peripheral vision while looking down that sniper scope can get you killed.

The next consideration is the defenses of your opponents. Slow firing, high caliber weapons like Sniper Rifles and Pistols chew through Armor, but are weak against Biotic Barriers and Shields. Rapid fire weapons with a lot of projectiles, by contrast, like SMG's and Shotguns chew up Shields and Barriers quickly, but have trouble with armor. Assault Rufles are a bit of an odd duck as they're 'pretty good' at handling everything.

Additionally there are mods availiable for several weapon types that alter their capabilities. You can add Armor-penetration to an SMG or a shotgun, or a melee upgrade to a pistol or shotgun. Maybe a scope on your SMG to improve its mid-long range performance?

Finally, you may want to pair some weapons up with certain specialty ammo. For instance, SMG's are devestating in combination with Cryo or Incendiary Ammo as their high rate of fire gives them more opportunities to proc the special effects provided by these ammo types than, say, a slow firing shotgun.